Variable response of human cells to polyinosinic-polycytidylic acid.
نویسنده
چکیده
Human cells derived from various organs of a single embryo responded variably to polyinosinic-polycytidylic acid with respect to induction of antiviral resistance and interferon.
منابع مشابه
مقایسه تأثیر Tumor Necrosis Factor-α، Monocyte Conditioned Medium و polyinosinic-polycytidylic acid در بلوغ سلول‌های دندریتیک
Abstract Background and purpose: Different laboratories have considered different maturation factors for producing human dendritic cells (DC) from peripheral blood monocytes. In this study, we comprehensively investigated the effect of adding poly (I:C) to standard maturation stimulus, i.e. MCM and TNF-α on the induction of T cell response. Materials and methods: Peripheral blood monocytes ...
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Polyinosinic-polycytidylic acid temporarily inhibits the growth rate of visible, transplanted tumors of both chemical (methylcholanthrene-induced fibrosarcomas) and viral (murine poly orna) origin with nearly equal facility. This effect is dose related and is associated with lymphopenia and death at high doses or following prolonged administration. Polyinosinicpolycytidylic acid produces a vari...
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When Detroit cells are infected with poliovirus in the presence of 5/~g./ml. of actinomycin, cell-controlled RNA synthesis is blocked and 2-[14C]uridine is incorporated only into poliovirus-specific RNA. The addition of polyinosinic-polycytidylic acid (5/%/ml.) under such conditions results in the inhibition of synthesis of 35s intracellular, infectious poliovirus RNA. A high molecular weight f...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 3 5 شماره
صفحات -
تاریخ انتشار 1973